Endothelin receptor antagonist :
Endothelin receptor antagonist (ERA) is a drug that blocks endothelin receptors. Blocks the actions of endothelin. Inhibition of endothelin can reduce tumor growth, progression and angiogenesis.
three types of endothelin receptor antagonists
(A) Selective ET A receptor antagonists such as :
sitaxentan,
ambrisentan,
atrasentan,
BQ-123 ,
zibotenten,
that affect endothelin A receptors.
(B) dual opposites such as :
bosenton,
macitentan,
tezosentan,
which affect both the endothelin A and B receptors.
(C) Selective ET B receptor antagonists such as :
BQ-788,
A192621,
Those affecting the endothelin B receptors are used in research.
Bosenton:
Bosentan is used to treat pulmonary arterial hypertension.
Machitanton :
Macitentan is used to manage pulmonary arterial hypertension to delay the progression of the disease.
Darusentan:
Darusentan is used to treat congestive heart failure and high blood pressure.
Actelion:
Actelion is used in cardiovascular disorders, hypertension, and pulmonary hypertension.
TBC-3711 :
TBC-3711 is used for the treatment of congestive heart failure, hypertension, and pulmonary hypertension.
Sitaxenton :
Sitaxanten is used for the treatment of pulmonary hypertension, connective tissue disease, hypertension, and congestive heart failure.
Enrasentan:
Enrasentan is used for the treatment of congestive heart failure, chronic obstructive pulmonary disease (COPD), and benign prostatic hyperplasia.
BQ-123 :
BQ-123 is used for the treatment of coronary artery disease, aorto-coronary bypass grafting, and ST-elevation myocardial infarction.
AMBRISENTANE :
Ambrisentan is used for the treatment of pulmonary arterial hypertension and pulmonary arterial hypertension.