Mallory-Denk Bodies (मैलोरी-डेंक बॉडीज) हिपेटोसाइट्स (liver cells) में पाए जाने वाले abnormal cytoplasmic inclusions हैं।
- पहले इन्हें Mallory bodies कहा जाता था, अब Mallory-Denk bodies updated term है।
- यह alcoholic liver disease, non-alcoholic steatohepatitis (NASH), Wilson’s disease, primary biliary cholangitis जैसी liver conditions में देखे जाते हैं।
- Histologically, ये eosinophilic, rope-like cytoplasmic aggregates होते हैं।
Mallory-Denk Bodies क्या हैं (What are Mallory-Denk Bodies)
- Aggregates of intermediate filaments (keratin 8 and 18) in liver cells
- Associated with cellular stress and liver injury
- Seen in alcoholic hepatitis, non-alcoholic fatty liver disease, drug-induced liver injury
- Indicative of chronic liver damage and inflammation
Mallory-Denk Bodies कारण (Causes of Mallory-Denk Bodies)
1. Alcoholic Liver Disease
- Chronic alcohol consumption leads to hepatocyte injury
- Most common cause
2. Non-Alcoholic Steatohepatitis (NASH)
- Fatty liver with inflammation
- Metabolic syndrome, obesity, diabetes increase risk
3. Drugs and Toxins
- Amiodarone, methotrexate, tamoxifen can induce Mallory-Denk bodies
4. Genetic & Metabolic Disorders
- Wilson’s disease
- Primary biliary cholangitis
5. Other Liver Injuries
- Viral hepatitis
- Chronic cholestasis
Mallory-Denk Bodies लक्षण (Symptoms associated with conditions having Mallory-Denk Bodies)
Mallory-Denk bodies themselves symptoms नहीं देते, लेकिन associated liver disease में शामिल हैं:
- Fatigue (थकान)
- Jaundice (पीली त्वचा और आंखें)
- Abdominal discomfort (upper right quadrant pain)
- Hepatomegaly (enlarged liver)
- Nausea, vomiting, loss of appetite
- Advanced cases: ascites, variceal bleeding, liver failure
Symptom severity depends on underlying liver disease।
Mallory-Denk Bodies कैसे पहचाने (Diagnosis of Mallory-Denk Bodies)
- Liver Biopsy – Histopathology shows eosinophilic cytoplasmic inclusions
- Immunohistochemistry – stains for keratin 8/18, ubiquitin
- Blood Tests – elevated liver enzymes (AST, ALT, ALP)
- Imaging – Ultrasound / CT for fatty liver or cirrhosis
- Clinical History – alcohol intake, metabolic disorders, drug history
Mallory-Denk bodies are a histological marker, not a standalone diagnosis।
Mallory-Denk Bodies इलाज (Treatment / Management)
1. Address Underlying Cause
- Stop alcohol consumption in alcoholic liver disease
- Treat metabolic syndrome in NASH
- Adjust hepatotoxic medications
2. Supportive Liver Therapy
- Nutritional support, antioxidants
- Vitamin supplementation (Thiamine, B-complex)
- Control comorbidities (diabetes, hypertension)
3. Advanced Disease Management
- Management of cirrhosis complications: ascites, varices, hepatic encephalopathy
- Liver transplantation in end-stage liver disease
4. Monitoring
- Regular liver function tests
- Imaging for fibrosis or cirrhosis progression
Early intervention can prevent progression to cirrhosis or liver failure।
रोकथाम (Prevention)
- Limit alcohol intake
- Maintain healthy BMI and lifestyle
- Manage diabetes, hypertension, and metabolic syndrome
- Avoid unnecessary hepatotoxic drugs
- Regular liver check-ups in high-risk individuals
सावधानियाँ (Precautions)
- Monitor liver enzymes periodically if on hepatotoxic medications
- Seek medical attention for persistent fatigue, jaundice, or abdominal pain
- Avoid alcohol and substances that stress liver
- Follow diet and exercise recommendations for liver health
FAQs (अक्सर पूछे जाने वाले प्रश्न)
Q1. क्या Mallory-Denk bodies cancer हैं?
नहीं, ये benign histological markers हैं, लेकिन indicate करते हैं कि liver damage हो रहा है।
Q2. क्या ये सिर्फ शराब वालों में होते हैं?
नहीं, NASH, drugs, metabolic and genetic disorders में भी पाए जाते हैं।
Q3. क्या इनसे symptoms होते हैं?
सीधे नहीं, लेकिन associated liver disease के symptoms दिखाई देते हैं।
Q4. Prognosis कैसा है?
Depends on underlying liver condition; early lifestyle modification और treatment से outcome बेहतर होता है।
निष्कर्ष (Conclusion)
Mallory-Denk Bodies (मैलोरी-डेंक बॉडीज) liver cells में बनने वाले cytoplasmic aggregates हैं जो chronic liver injury और stress को दर्शाते हैं।
Underlying liver disease को manage करना, alcohol और toxins से बचना, nutritional support और regular monitoring से progression रोकना संभव है।
अगर किसी को fatigue, jaundice, abdominal discomfort या liver disease के संकेत दिखें, तो तुरंत hepatologist / physician से consultation करना चाहिए।