Mucinous Carcinoma (म्यूसीनस कार्सिनोमा) एक प्रकार का rare adenocarcinoma है जिसमें tumor cells mucin (gel-like secretion) बनाते हैं।
- यह cancer आमतौर पर breast (स्तन), colon, pancreas, skin, और other organs में पाया जाता है।
- Histologically, यह tumor extracellular mucin pools में floating tumor cells के रूप में दिखता है।
- Mucinous carcinoma अन्य carcinoma types की तुलना में slow-growing और prognosis बेहतर हो सकता है, लेकिन early diagnosis जरूरी है।
Mucinous Carcinoma क्या है (What is Mucinous Carcinoma)
- Tumor में high mucin content होता है, जो इसे gel-like appearance देता है।
- Microscopically, tumor cells floating islands in mucin pools दिखाई देते हैं।
- Breast में common – postmenopausal women में अधिक incidence
- Skin या gastrointestinal tract में भी rare cases पाए जाते हैं
Mucinous Carcinoma कारण (Causes of Mucinous Carcinoma)
1. Genetic Factors
- BRCA mutations (rare)
- Familial adenomatous polyposis (colon mucinous carcinoma)
2. Environmental / Lifestyle Factors
- Smoking (lung, pancreatic cases)
- Diet – high fat, low fiber (colon mucinous carcinoma)
- Alcohol – increased risk in GI tract
3. Age & Hormonal Factors
- Breast mucinous carcinoma – usually postmenopausal women
- Hormonal influences (estrogen, progesterone receptors positive in breast cases)
4. Other Factors
- Chronic inflammation or pre-existing lesions in colon, pancreas, or skin
Mucinous Carcinoma लक्षण (Symptoms of Mucinous Carcinoma)
Organ-specific presentation:
1. Breast Mucinous Carcinoma
- Slowly growing painless lump
- Well-circumscribed mass, sometimes soft or gelatinous
- Rare nipple discharge
2. Colorectal / Gastrointestinal
- Change in bowel habits
- Abdominal pain, bleeding per rectum
- Weight loss
3. Skin Mucinous Carcinoma
- Nodular lesion, usually on head, neck, or eyelids
- Slowly enlarging, sometimes ulcerated
4. General Symptoms
- Fatigue, weight loss (advanced cases)
- Local invasion or lymph node involvement
Symptoms depend on affected organ and tumor size।
Mucinous Carcinoma कैसे पहचाने (Diagnosis of Mucinous Carcinoma)
- Clinical Examination – palpable mass or lesion
- Imaging Studies – mammography, ultrasound, CT/MRI for internal organs
- Biopsy & Histopathology – confirmatory diagnosis (mucin pools with tumor cells)
- Immunohistochemistry – hormone receptor status in breast cases
- Staging Tests – PET scan, lymph node evaluation
Early diagnosis improves treatment outcomes and prognosis।
Mucinous Carcinoma इलाज (Treatment of Mucinous Carcinoma)
1. Surgical Management
- Breast – lumpectomy or mastectomy
- Colon / GI – segmental resection
- Skin – wide local excision
2. Chemotherapy / Radiotherapy
- Based on tumor stage and organ involved
- Breast mucinous carcinoma – usually hormone receptor positive, chemo less aggressive
- Advanced GI mucinous carcinoma – chemotherapy required
3. Hormonal Therapy (Breast Cases)
- Tamoxifen or aromatase inhibitors if ER/PR positive
4. Follow-up & Monitoring
- Regular imaging and blood tests
- Monitor for recurrence or metastasis
रोकथाम (Prevention)
- Healthy diet, exercise, avoid smoking/alcohol
- Regular cancer screenings (mammography, colonoscopy)
- Awareness of family history
- Early evaluation of any painless lumps or nodules
सावधानियाँ (Precautions)
- Lump या lesion को ignore न करें
- Biopsy और histopathology confirm करना जरूरी है
- Hormone therapy या chemotherapy केवल doctor supervision में
- Regular follow-up – especially post-surgery
FAQs (अक्सर पूछे जाने वाले प्रश्न)
Q1. Mucinous carcinoma aggressive होता है?
Breast mucinous carcinoma usually slow-growing और low-grade होता है; GI या pancreatic cases aggressive हो सकते हैं।
Q2. क्या surgery पर्याप्त है?
Early localized tumors में surgery sufficient है, advanced stage में additional therapy जरूरी।
Q3. Prognosis कैसा होता है?
Breast mucinous carcinoma – generally favorable prognosis; GI or pancreatic – stage dependent।
Q4. क्या यह genetic है?
कुछ rare cases में genetic predisposition होता है, ज्यादातर sporadic।
निष्कर्ष (Conclusion)
Mucinous Carcinoma (म्यूसीनस कार्सिनोमा) एक rare subtype of adenocarcinoma है।
Early detection, organ-specific surgery, adjunct chemotherapy/hormonal therapy और regular follow-up से treatment outcomes बेहतर होते हैं।
अगर कोई slow-growing lump, nodule, या GI symptoms हों, तो तुरंत oncologist या specialist doctor से consultation करें।