Dapagliflozin and Sacubitril/Valsartan Uses, Dosage, Side Effects & Precautions
What is Dapagliflozin and Sacubitril/Valsartan?
Dapagliflozin and Sacubitril/Valsartan is a combination therapy primarily used in the management of heart failure and associated conditions. This combination targets multiple pathways involved in heart failure, helping to improve heart function, reduce hospitalizations, and improve overall quality of life in patients with chronic heart conditions.
This medicine is generally prescribed to patients with heart failure with reduced ejection fraction (HFrEF), sometimes along with diabetes or kidney-related complications.
Composition of Dapagliflozin and Sacubitril/Valsartan
This combination contains three active ingredients:
Dapagliflozin – An SGLT2 inhibitor
Sacubitril – A neprilysin inhibitor
Valsartan – An angiotensin II receptor blocker (ARB)
Each component works differently but complements the others for better cardiovascular protection.
Uses of Dapagliflozin and Sacubitril/Valsartan
This combination is commonly used for:
Chronic heart failure (HFrEF)
Reducing the risk of hospitalization due to heart failure
Improving heart pumping efficiency
Managing heart failure in patients with or without type 2 diabetes
Protecting kidney function in heart failure patients
Reducing cardiovascular-related mortality
How Does Dapagliflozin and Sacubitril/Valsartan Work?
1. Dapagliflozin
Removes excess glucose and sodium through urine
Reduces fluid overload
Lowers pressure on the heart
Improves heart and kidney outcomes
2. Sacubitril
Inhibits neprilysin enzyme
Increases beneficial peptides that relax blood vessels
Reduces sodium retention and heart stress
3. Valsartan
Blocks angiotensin II receptors
Prevents blood vessel tightening
Lowers blood pressure
Reduces strain on the hear
Together, these medicines:
Reduce fluid overload
Improve heart efficiency
Decrease disease progression
Dosage and How to Take Dapagliflozin and Sacubitril/Valsartan
Dosage is decided by the doctor based on:
Age
Kidney function
Blood pressure
Severity of heart failure
General Instructions:
Take the medicine once daily, or as prescribed
Can be taken with or without food
Take it at the same time every day
Swallow whole with water
Do not crush or chew the tablet
Never change the dose or stop the medicine without medical advice
Precautions to Take
Before using this medicine, inform your doctor if you have:
Low blood pressure
Kidney or liver disease
History of dehydration
Electrolyte imbalance (low sodium or potassium)
Diabetes with frequent infections
History of angioedema
Pregnancy or breastfeeding
Special Precautions:
Monitor blood pressure regularly
Maintain proper hydration
Regular kidney function tests may be required
Avoid excessive alcohol consumption
Side Effects of Dapagliflozin and Sacubitril/Valsartan
Common Side Effects:
Low blood pressure (dizziness, lightheadedness)
Increased urination
Fatigue
Headache
Nausea
Less Common but Serious Side Effects:
Kidney function changes
High potassium levels
Urinary or genital infections
Severe dehydration
Angioedema (swelling of face, lips, tongue – rare but serious)
Seek medical help immediately if you experience severe swelling, difficulty breathing, or fainting.
Storage Instructions
Store at room temperature (below 25°C)
Keep away from moisture and heat
Keep out of reach of children
Do not use after the expiry date
Packaging and Availability
Available in strip or blister packaging
Strengths and combinations may vary by manufacturer
Available only on doctor’s prescription
Commonly supplied in packs of 10 or 14 tablets
Disclaimer
This article is for educational purposes only and does not replace professional medical advice. Always consult your doctor before starting any new medication.