Myxoid Liposarcoma (मिक्सॉइड लिपोसार्कोमा) एक rare malignant tumor है जो soft tissue (मुलायम ऊतक) में विकसित होता है।
- यह adipose tissue (body fat) से उत्पन्न होता है।
- Most commonly thigh (जांघ), retroperitoneum, और extremities में पाया जाता है।
- Tumor में myxoid (gel-like) stroma और lipoblast cells होते हैं।
- Aggressive हो सकता है, लेकिन early detection और treatment से prognosis अच्छा है।
Myxoid Liposarcoma क्या है (What is Myxoid Liposarcoma)
- A type of soft tissue sarcoma
- Tumor cells में fat differentiation और myxoid matrix होता है
- Slowly growing mass initially painless, फिर local discomfort या pressure symptoms दे सकता है
- Rarely metastasize to lungs, bones, or other organs
Myxoid Liposarcoma कारण (Causes of Myxoid Liposarcoma)
1. Genetic Factors
- Chromosomal translocations (t(12;16)(q13;p11)) – FUS-DDIT3 fusion gene
- Rare familial predisposition
2. Environmental Factors
- Radiation exposure in past
- Chronic lymphedema or trauma (rare)
3. Unknown / Idiopathic
- Most cases occur without clear risk factors
Myxoid Liposarcoma लक्षण (Symptoms of Myxoid Liposarcoma)
- Painless, slowly growing lump (most common)
- Swelling in thigh, buttock, or extremities
- Occasionally tenderness or discomfort if compressing nerves
- Rare: restricted movement or neurological symptoms
- Advanced cases: weight loss, fatigue
Tumor early stage में subtle होता है और अक्सर incidental detection होता है।
Myxoid Liposarcoma कैसे पहचाने (Diagnosis of Myxoid Liposarcoma)
- Physical Examination – firm, deep-seated mass
- Imaging – MRI preferred for soft tissue tumors; CT scan for retroperitoneal lesions
- Biopsy – core needle biopsy to confirm malignancy
- Histopathology – myxoid stroma, lipoblasts, vascular pattern
- Genetic Testing – detection of FUS-DDIT3 fusion gene in some cases
- Staging – Chest CT for lung metastasis
Accurate diagnosis essential for treatment planning।
Myxoid Liposarcoma इलाज (Treatment of Myxoid Liposarcoma)
1. Surgical Treatment
- Wide local excision with clear margins
- Limb-sparing surgery preferred for extremity tumors
2. Radiotherapy
- Preoperative or postoperative to reduce recurrence risk
- Particularly for deep or large tumors
3. Chemotherapy
- Doxorubicin or ifosfamide based regimen in high-grade or metastatic cases
- Response rate varies
4. Targeted Therapy / Experimental
- Clinical trials ongoing for novel agents targeting genetic mutations
5. Follow-up & Monitoring
- Regular MRI/CT scans for local recurrence and metastasis
- Long-term surveillance critical
Early and complete surgical excision gives best prognosis।
रोकथाम (Prevention)
- No guaranteed prevention due to genetic/idiopathic nature
- Early medical evaluation for persistent lumps or swelling
- Avoid unnecessary radiation exposure
- Regular follow-up in high-risk individuals
सावधानियाँ (Precautions)
- Do not ignore deep-seated painless lumps
- Avoid self-treatment or massage of tumor site
- Strict adherence to treatment and follow-up schedule
- Prompt reporting of new swelling, pain, or systemic symptoms
FAQs (अक्सर पूछे जाने वाले प्रश्न)
Q1. Myxoid liposarcoma कितनी aggressive होती है?
Typically slow-growing, लेकिन high-grade tumors rapid growth और metastasis कर सकते हैं।
Q2. Surgery के बाद recurrence कितनी common है?
Wide excision के बाद recurrence कम होती है, लेकिन deep tumors में follow-up जरूरी है।
Q3. क्या यह metastasize करता है?
हाँ, rare cases में lungs, bones, और retroperitoneum में spread हो सकता है।
Q4. Prognosis कैसा है?
Early diagnosis और complete excision से 5-year survival 70–90% हो सकती है।
निष्कर्ष (Conclusion)
Myxoid Liposarcoma (मिक्सॉइड लिपोसार्कोमा) एक rare soft tissue malignancy है।
Early detection, accurate diagnosis, surgical excision और appropriate adjuvant therapy से prognosis बेहतर किया जा सकता है।
अगर किसी को slow-growing painless lump दिखे, तो oncologist या surgical specialist से तुरंत consultation जरूरी है