Myxomatous Degeneration (मिक्सोमेटस डिजेनेरेशन) एक connective tissue disorder है जिसमें tissue structure कमजोर और gelatinous (myxoid) हो जाता है।
- Heart valves, especially mitral valve, में अक्सर देखा जाता है। इसे Mitral Valve Prolapse (MVP) के साथ associate किया जाता है।
- Connective tissue abnormalities से leaflets thin, redundant और elongated हो जाते हैं।
- Condition progressive हो सकती है और heart function को प्रभावित कर सकती है।
Myxomatous Degeneration क्या है (What is Myxomatous Degeneration)
- Degenerative change of connective tissue, characterized by accumulation of mucopolysaccharides (myxoid material)
- Commonly affects mitral valve (posterior leaflet)
- Leaflets become thickened, redundant, and floppy
- Leads to mitral regurgitation (MR) in advanced cases
Myxomatous Degeneration कारण (Causes of Myxomatous Degeneration)
1. Genetic Factors
- Familial predisposition in some cases
- Connective tissue disorders like Marfan syndrome, Ehlers-Danlos syndrome
2. Age-related Degeneration
- Progressive weakening of connective tissue with age
- More common in middle-aged women
3. Mechanical Stress
- Long-term stress on mitral valve
- Hypertension, left ventricular enlargement
4. Idiopathic
- Many cases without clear cause
Myxomatous Degeneration लक्षण (Symptoms of Myxomatous Degeneration)
Mild cases asymptomatic, but symptomatic patients में शामिल हैं:
- Palpitations or irregular heartbeat
- Chest discomfort or mild pain
- Fatigue or shortness of breath
- Mitral regurgitation – murmur detected on auscultation
- Rarely, arrhythmias or sudden cardiac events
Symptoms often appear if valve regurgitation develops।
Myxomatous Degeneration कैसे पहचाने (Diagnosis of Myxomatous Degeneration)
- Echocardiography (TTE / TEE) – thickened, redundant mitral valve leaflets, prolapse detection
- Physical Examination – mid-systolic click, murmur
- ECG – may show arrhythmias
- MRI / CT (rarely) – detailed anatomy
- Family history – genetic predisposition
Echocardiography is gold standard for diagnosis।
Myxomatous Degeneration इलाज (Treatment of Myxomatous Degeneration)
1. Medical Management
- Beta-blockers – control palpitations and mild symptoms
- ACE inhibitors / ARBs – if associated mitral regurgitation and LV dysfunction
- Lifestyle modification – avoid stimulants, manage hypertension
2. Surgical Treatment
- Mitral valve repair or replacement – in severe regurgitation
- Preferred over replacement if feasible for better long-term outcome
3. Regular Monitoring
- Echocardiography every 6–12 months
- Monitor symptoms and valve function
रोकथाम (Prevention)
- Genetic counseling in familial cases
- Early detection in patients with connective tissue disorders
- Control blood pressure and heart disease
- Avoid activities that excessively strain the heart
सावधानियाँ (Precautions)
- Regular follow-up with cardiologist
- Monitor for palpitations, shortness of breath, or fatigue
- Avoid unnecessary medications that increase heart rate
- Seek immediate care for chest pain or syncope
FAQs (अक्सर पूछे जाने वाले प्रश्न)
Q1. Myxomatous degeneration serious है?
Mild cases mostly benign हैं, लेकिन severe mitral regurgitation में heart failure और arrhythmias हो सकते हैं।
Q2. Surgery कब जरूरी होती है?
Severe mitral regurgitation, symptomatic patients, or progressive valve dysfunction में।
Q3. क्या यह genetic है?
कुछ cases में genetic predisposition होता है, खासकर Marfan और Ehlers-Danlos syndrome में।
Q4. Symptoms कभी नहीं दिखते तो क्या करना चाहिए?
Regular echocardiography और cardiology follow-up recommended है।
निष्कर्ष (Conclusion)
Myxomatous Degeneration (मिक्सोमेटस डिजेनेरेशन) connective tissue disorder है, जो mitral valve prolapse और regurgitation से जुड़ा हो सकता है।
Early detection, regular monitoring, symptom management और timely surgical intervention से complications को prevent किया जा सकता है।
अगर किसी को palpitations, chest discomfort या fatigue महसूस हो, तो तुरंत cardiologist से consultation जरूरी है